Tune it down to live it up? Rapid, nongenomic effects of cortisol on the human brain.
Identifieur interne : 000698 ( Main/Exploration ); précédent : 000697; suivant : 000699Tune it down to live it up? Rapid, nongenomic effects of cortisol on the human brain.
Auteurs : Florian Strelzyk [Allemagne] ; Michael Hermes ; Ewald Naumann ; Melly Oitzl ; Christoph Walter ; Hans-Peter Busch ; Steffen Richter ; Hartmut Sch ChingerSource :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 1529-2401 ] ; 2012.
English descriptors
- KwdEn :
- Adaptation, Physiological (drug effects), Adaptation, Physiological (physiology), Adult, Anti-Inflammatory Agents (administration & dosage), Brain (drug effects), Brain (physiology), Caudate Nucleus (drug effects), Caudate Nucleus (physiology), Humans, Hydrocortisone (administration & dosage), Hydrocortisone (physiology), Hypothalamo-Hypophyseal System (drug effects), Hypothalamo-Hypophyseal System (physiology), Injections, Intravenous, Male, Neural Pathways (drug effects), Neural Pathways (physiology), Thalamus (drug effects), Thalamus (physiology), Young Adult.
- MESH :
- chemical , administration & dosage : Anti-Inflammatory Agents, Hydrocortisone.
- drug effects : Adaptation, Physiological, Brain, Caudate Nucleus, Hypothalamo-Hypophyseal System, Neural Pathways, Thalamus.
- physiology : Adaptation, Physiological, Brain, Caudate Nucleus, Hydrocortisone, Hypothalamo-Hypophyseal System, Neural Pathways, Thalamus.
- Adult, Humans, Injections, Intravenous, Male, Young Adult.
Abstract
The stress hormone cortisol acts on the brain, supporting adaptation and time-adjusted coping processes. Whereas previous research has focused on slow emerging, genomic effects of cortisol, we addressed the rapid, nongenomic cortisol effects on in vivo neuronal activity in humans. Three independent placebo-controlled studies in healthy men were conducted. We observed changes in CNS activity within 15 min after intravenous administration of a physiological dose of 4 mg of cortisol (hydrocortisone). Two of the studies demonstrated a rapid bilateral thalamic perfusion decrement using continuous arterial spin labeling. The third study revealed rapid, cortisol-induced changes in global signal strength and map dissimilarity of the electroencephalogram. Our data demonstrate that a physiological concentration of cortisol profoundly affects the functioning and perfusion of the human brain in vivo via a rapid, nongenomic mechanism. The changes in neuronal functioning suggest that cortisol acts on the thalamic relay of background as well as on task-specific sensory information, allowing focus and facilitation of adaptation to challenges.
DOI: 10.1523/JNEUROSCI.2384-11.2012
PubMed: 22238097
Affiliations:
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Rapid, nongenomic effects of cortisol on the human brain.</title><author><name sortKey="Strelzyk, Florian" sort="Strelzyk, Florian" uniqKey="Strelzyk F" first="Florian" last="Strelzyk">Florian Strelzyk</name><affiliation wicri:level="4"><nlm:affiliation>Psychophysiological Laboratory of the University of Trier, 54286 Trier, Germany. florian@strelzyk.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Psychophysiological Laboratory of the University of Trier, 54286 Trier</wicri:regionArea><wicri:noRegion>54286 Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Hermes, Michael" sort="Hermes, Michael" uniqKey="Hermes M" first="Michael" last="Hermes">Michael Hermes</name></author><author><name sortKey="Naumann, Ewald" sort="Naumann, Ewald" uniqKey="Naumann E" first="Ewald" last="Naumann">Ewald Naumann</name></author><author><name sortKey="Oitzl, Melly" sort="Oitzl, Melly" uniqKey="Oitzl M" first="Melly" last="Oitzl">Melly Oitzl</name></author><author><name sortKey="Walter, Christoph" sort="Walter, Christoph" uniqKey="Walter C" first="Christoph" last="Walter">Christoph Walter</name></author><author><name sortKey="Busch, Hans Peter" sort="Busch, Hans Peter" uniqKey="Busch H" first="Hans-Peter" last="Busch">Hans-Peter Busch</name></author><author><name sortKey="Richter, Steffen" sort="Richter, Steffen" uniqKey="Richter S" first="Steffen" last="Richter">Steffen Richter</name></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name></author></analytic><series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title><idno type="eISSN">1529-2401</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological (drug effects)</term><term>Adaptation, Physiological (physiology)</term><term>Adult</term><term>Anti-Inflammatory Agents (administration & dosage)</term><term>Brain (drug effects)</term><term>Brain (physiology)</term><term>Caudate Nucleus (drug effects)</term><term>Caudate Nucleus (physiology)</term><term>Humans</term><term>Hydrocortisone (administration & dosage)</term><term>Hydrocortisone (physiology)</term><term>Hypothalamo-Hypophyseal System (drug effects)</term><term>Hypothalamo-Hypophyseal System (physiology)</term><term>Injections, Intravenous</term><term>Male</term><term>Neural Pathways (drug effects)</term><term>Neural Pathways (physiology)</term><term>Thalamus (drug effects)</term><term>Thalamus (physiology)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Adaptation, Physiological</term><term>Brain</term><term>Caudate Nucleus</term><term>Hypothalamo-Hypophyseal System</term><term>Neural Pathways</term><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Adaptation, Physiological</term><term>Brain</term><term>Caudate Nucleus</term><term>Hydrocortisone</term><term>Hypothalamo-Hypophyseal System</term><term>Neural Pathways</term><term>Thalamus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term><term>Injections, Intravenous</term><term>Male</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The stress hormone cortisol acts on the brain, supporting adaptation and time-adjusted coping processes. Whereas previous research has focused on slow emerging, genomic effects of cortisol, we addressed the rapid, nongenomic cortisol effects on in vivo neuronal activity in humans. Three independent placebo-controlled studies in healthy men were conducted. We observed changes in CNS activity within 15 min after intravenous administration of a physiological dose of 4 mg of cortisol (hydrocortisone). Two of the studies demonstrated a rapid bilateral thalamic perfusion decrement using continuous arterial spin labeling. The third study revealed rapid, cortisol-induced changes in global signal strength and map dissimilarity of the electroencephalogram. Our data demonstrate that a physiological concentration of cortisol profoundly affects the functioning and perfusion of the human brain in vivo via a rapid, nongenomic mechanism. The changes in neuronal functioning suggest that cortisol acts on the thalamic relay of background as well as on task-specific sensory information, allowing focus and facilitation of adaptation to challenges.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Rhénanie-Palatinat</li></region><settlement><li>Trèves (Allemagne)</li></settlement><orgName><li>Université de Trèves</li></orgName></list><tree><noCountry><name sortKey="Busch, Hans Peter" sort="Busch, Hans Peter" uniqKey="Busch H" first="Hans-Peter" last="Busch">Hans-Peter Busch</name><name sortKey="Hermes, Michael" sort="Hermes, Michael" uniqKey="Hermes M" first="Michael" last="Hermes">Michael Hermes</name><name sortKey="Naumann, Ewald" sort="Naumann, Ewald" uniqKey="Naumann E" first="Ewald" last="Naumann">Ewald Naumann</name><name sortKey="Oitzl, Melly" sort="Oitzl, Melly" uniqKey="Oitzl M" first="Melly" last="Oitzl">Melly Oitzl</name><name sortKey="Richter, Steffen" sort="Richter, Steffen" uniqKey="Richter S" first="Steffen" last="Richter">Steffen Richter</name><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name><name sortKey="Walter, Christoph" sort="Walter, Christoph" uniqKey="Walter C" first="Christoph" last="Walter">Christoph Walter</name></noCountry><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Strelzyk, Florian" sort="Strelzyk, Florian" uniqKey="Strelzyk F" first="Florian" last="Strelzyk">Florian Strelzyk</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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